AryoTrust

AryoTrust

is a biosimilar product with the generic name of Trastuzumab. AryoTrust is a recombinant DNA-derived humanized monoclonal antibody that selectively targets the extracellular domain of the human epidermal growth factor receptor 2 protein (HER2). These receptors are normally present on the normal cell surfaces leading to cellular growth and proliferation. Over-expression of HER2 is observed in primary breast and advanced gastric cancer cells. A consequence of HER2 gene amplification is an increase in HER2 protein expression on the surface of these tumor cells, which results in a constitutively activated HER2 receptor and growth of cancerous cells. AryoTrust binds to HER2 and prevents its activity and leads to the death of cancer cells.

AryoTrust  is used for:

AryoTrust is produced in the form of lyophilized powder for concentrate for solution for infusion in two dosages of 150 mg and 440 mg which is administered as intravenous infusion after dilution. Each single use vial of 150 mg AryoTrust contains 150 mg Trastuzumab and should be dissolved with 7.2 ml of sterile Water for Injections. Each small box contains 1 vial of powder and a patient information leaflet. AryoTrust 440 mg contains 440 mg Trastuzumab and should be dissolved with 20 ml of Bacteriostatic Water for Injection (BWFI). Each small box contains 1 vial of powder, 1 vial of BWFI and a patient information leaflet.